Comprehensive Guide for Regional Agents. Understanding the mechanism of SAO in Neuro-regeneration, Oncology Support, and Anti-aging.
Exogenous Supplementation
Supplementing neurotransmitters or vitamins. Symptom control only. Often fails to reverse damage.
Endogenous Induction
Binding Siglec receptors to upregulate endogenous factors (IGF-1, HGF) by >50%. Structural repair.
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SAO mimics endogenous Polysialic Acid (PSA), acting as a "molecular decoy" to bind Siglec-11 receptors on Microglia.
Result: Anti-inflammatory "Ceasefire" signal sent to brain immune cells.
Clinical observation confirms patients recover "Facial Recognition" (Social Memory) after 60 days (8 weeks). This aligns with the Adult Hippocampal Neurogenesis (AHN) cycle triggered by SAO intake.
IGF-1 activates mTOR pathway, increasing AMPA receptors.
Unblocks CD33 receptors, restoring Microglia phagocytosis.
IGF-1 triggers Neural Stem Cell division. Sleep quality improves.
New neurons extend axons towards CA2/CA3. HGF fuels energy.
Clinical Breakthrough: Synapses connect to memory net. Facial recognition restored.
How paralyzed patients regain walking ability through "Vicariation" (Neural Compensation).
Unlike VEGF, HGF induces angiogenesis in the Ischemic Penumbra without causing brain edema.
Senolytic Action: Specifically induces apoptosis in senescent Glial Scar cells that block nerve regeneration.
A multi-target adjuvant therapy system designed to address Inflammation, Clearance, and Regeneration (AIF-2 + PLG-2 + SAO).
Magdisalicylate® selectively inhibits COX-2, cutting off the inflammatory "fuel" (PGE2) that drives tumor growth and immune evasion.
Senolytic Effect: Piperlongumine uses ROS selective toxicity to clear senescent "zombie cells" and chemo-resistant residue without harming normal cells.
Acts as a bio-stimulant to upregulate IGF-1 and EGF. Repairs mucosal barriers damaged by chemotherapy and reverses Cachexia (muscle wasting).
Topical application of SAO lotion demonstrates powerful endogenous regeneration, acting on fibroblasts to accelerate wound healing and moisture retention.
Compared to non-additive control, SAO induction increased Type 1 Collagen production by approximately 20 times.
Significant increase in skin hydration after 4 weeks of topical SAO lotion application.
Consistent hydration improvement observed across different facial zones.
Clinical data on Sarcopenia (Muscle Loss) and Hair Growth using SAO combinations.
Outcome: "Walking became easy," "No stumbles," "Joint pain disappeared."
Outcome: "Hair loss dramatically decreased," "Hair growth speed increased."