Regenerative Medicine Report

Global Breakthrough:
60-Day Oral Regimen
To Reverse Alzheimer's

Restarting the brain's repair factory (IGF-1 & HGF) through systemic intake.

Traditional Paradigm

Exogenous Supplementation

Supplementing neurotransmitters (Donepezil). Symptom control only.

New Paradigm (SAO)

Endogenous Induction (Oral)

Binding Siglec receptors to upregulate factors by >50%. Structural repair & regeneration.

Protected by Global Patents

US Patent 10,610,537 B2
JP Patent 6762027
CN Patent ZL 201710725400.2
HK Patent 1250989

The Molecular Key

Specific Molecular Fingerprint

  • Molecular Weight: 1.7 - 2.3 kDa
  • Sialic Acid/Hexose Ratio: 0.5 - 0.9
  • Only this specific range can penetrate the Blood-Brain Barrier (BBB) and bind to Siglec receptors.

The "Siglec" Handshake

SAO mimics endogenous Polysialic Acid (PSA), acting as a "molecular decoy" to bind Siglec-11 receptors on Microglia.

Result: Anti-inflammatory "Ceasefire" signal sent to brain immune cells.

Factor Upregulation

IGF-1 (Neurogenesis) > 50%
HGF (Angiogenesis) > 50%
Col-1 (Scaffold) ~ 20x
Ischemic Stroke Intervention

The "Biological Bypass"

How paralyzed patients regain walking ability through "Vicariation" (Neural Compensation).

HGF: The Safe Architect

Unlike VEGF, HGF induces angiogenesis in the Ischemic Penumbra without causing brain edema. It delivers Oxygen & Glucose to dormant neurons.

Result: Resuscitates the "sleeping" functional area.

Piperlongumine: The Scavenger

Senolytic Action: Specifically induces apoptosis in senescent Glial Scar cells that block nerve regeneration.

Result: Physically clears the "roadblock" for axon regrowth.

*HGF activates Rho/ROCK pathway guiding axons through the cleared path to reconnect with the spinal cord.

Regenerative Dermatology

The "20x Collagen" Effect

Topical application of SAO lotion demonstrates powerful endogenous regeneration, acting on fibroblasts to accelerate wound healing and moisture retention.

~20x

Type 1 Collagen Synthesis

Compared to non-additive control, SAO induction increased Type 1 Collagen production by approximately 20 times.

22.9% 29.3%

Cheek Moisture (1 Month)

Significant increase in skin hydration after 4 weeks of topical SAO lotion application.

24.1% 29.5%

Forehead Moisture (1 Month)

Consistent hydration improvement observed across different facial zones.

Turnover Acceleration Mechanism

In Dan-syl chloride fluorescence tests, skin treated with SAO lotion showed faster disappearance of fluorescence compared to control, indicating significantly accelerated skin cell turnover and metabolic activity, particularly in subjects aged 50s-60s.

Systemic Regeneration Applications

Muscle & Hair Restoration

Clinical data on Sarcopenia (Muscle Loss) and Hair Growth using SAO combinations.

Sarcopenia Recovery

  • Subjects: Age 60-80s (Walking difficulty, joint pain).
  • Regimen: SAO + Whey Protein (5g/day) for 1 Month.
  • Result: 90% Improvement Rate (27/30 subjects).
Outcome: "Walking became easy," "No stumbles," "Pain in joints disappeared."

Hair Regeneration

  • Subjects: Males with sparse hair/hair loss.
  • Regimen: Topical SAO (0.05%) + Fucoidan (0.01%) for 1 Month.
  • Result: 85% Improvement Rate (6/7 subjects).
Outcome: "Hair loss dramatically decreased," "Hair growth speed increased."